It's possible but rare. There are lots of opportunities that bookies miss but over time they usually adjust. For example Wong Teasers (teasing through both the 3 and 7 in NFL) were highly profitable for a while and now evidence shows they are less so, if at all, as the info becomes public and books adjust payouts and shade teaser lines to compensate. So there are "loopholes" to try and exploit.

If you’ve ever been tempted by a flutter, you’ll know how bookmakers and casinos stack the odds against you. The clearest example is roulette, where there are 36 red and black numbers plus the green numbers 0 and (in the U.S.) 00. So that’s 38 possibilities in total. When betting on red or black, the odds of choosing correctly are 18/38, and a fair payout for a $1 stake is $2.111. However, the house pays only $2 and keeps the difference. In that way, it guarantees itself a profit.
My picks have yielded a much higher risk adjusted return than the stock market. Obviously, the variance from season to season is formidable, but as anyone who had a significant amount invested in stocks or real estate in 2008 can tell you, such swings aren’t limited to sports. In the long run, my edge in what I do is far greater than the edge that you could hope to gain in any other speculative market.

If you are a fan of sports betting you will LOVE Las Vegas. Being the only state in the union that allows legal betting on all of the major individual sports leagues and events, Las Vegas draws thousands of sports bettors year round. Almost all Las Vegas casinos feature a sportsbook and a number of big screen TVs which creates a great sports betting environment.

Straight-up bets, also known as the moneyline, are picks that are made on one club triumphing over the other. If Manchester City is playing Watford, in order to make a moneyline wager you’d need to pick one of those clubs to win. If you choose Man City and they do win, you’d win your moneyline bet. If the inverse happens and Watford wins, you’d lose your moneyline bet.
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