If you’ve ever been tempted by a flutter, you’ll know how bookmakers and casinos stack the odds against you. The clearest example is roulette, where there are 36 red and black numbers plus the green numbers 0 and (in the U.S.) 00. So that’s 38 possibilities in total. When betting on red or black, the odds of choosing correctly are 18/38, and a fair payout for a $1 stake is $2.111. However, the house pays only $2 and keeps the difference. In that way, it guarantees itself a profit.
Total O/U is the amount won on OVER or UNDER bets. When it comes to the Premier League, any factor that can influence the game can help you decide if you want to bet the OVER or the UNDER. These factors include how capable each club is on offense and defense, weather conditions (wind being especially influential since it can change how far/fast the ball travels when kicked), and injuries sustained before the match (real injuries, not the flopping around that is done in-game when a cleat grazes a player’s shin so slightly that the only thing you can do is roll your eyes at the telly). For example, if Man United’s goalkeeper suffers an injury to his hand and cannot play in their matchup against Brighton, you should take that into consideration when making your totals bet. You don’t know if their secondary netminder is going to let in more goals or play better against Brighton then their primary goalie.
It's unlikely/impossible that you can simplify things down to "bet any favorite in this situation" or "bet any total of
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ATS equals “against the spread”. The spread is the number oddsmakers use to give people other betting options besides only wins and losses. A spread for a Premier League fixture would be something like .5 or 1.5. One club would need to lose the match by no more than 1 or 2 goals or the other needs to win by 1, 2or more goals. If the final score doesn’t reflect the number set by the oddsmakers, your bet won’t cover the spread and you can’t win your bet.