Anything I can make guaranteed profit on. It is a Catch 22 though. The bigger leagues (NFL, NBA, MLB, NHL) have more people wagering on them, so the odds of finding lines that differ between sports books is tougher. This is because the betting line only moves when too many people are wagering on 1 side. A $100 will have little to no impact on a Super Bowl line that already has millions in the pot. As long as Vegas has close to equal action on each side, they profit every time. The lesser known sports, have less money wagered on each game, so it's easier to spot vastly different lines between different sports books.

It's possible but rare. There are lots of opportunities that bookies miss but over time they usually adjust. For example Wong Teasers (teasing through both the 3 and 7 in NFL) were highly profitable for a while and now evidence shows they are less so, if at all, as the info becomes public and books adjust payouts and shade teaser lines to compensate. So there are "loopholes" to try and exploit.
On December 7, 1980 the San Francisco 49ers overcame a halftime deficit of 28 points in what became the greatest regular season comeback victory in NFL regular season history. By the beginning of the third quarter, notorious Vegas bookmaker Frank Rosenthal received forfeiture notices from 246 San Francisco bettors totaling more than $25,000 in premature winnings. Rosenthal was able to retain these winnings despite the final outcome of the game due to gambling regulations previously established by the NAGRA.[citation needed]
The Thunder are faced with a seeding decision before tonight's tip against the Jazz at Vivint Smart. OKC's conundrum is whether they want to sell out in the final month of the regular season by playing their first rotation major minutes or saving their legs for postseason play. A focus on the team's final 16-games of the regular season to remain one of the top four seeds in the West requires playing Russell Westbrook and Paul George in excess of their season average in minutes played. This asking allot considering the pairs 36 minutes per game this season. 
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